Kafatos George, Andrews Nick, Nardone Anthony
Statistics Unit, Communicable Disease Surveillance Centre, Health Protection Agency Centre for Infections, 61 Colindale Avenue, London NW9 5EQ, UK.
Vaccine. 2005 Oct 10;23(42):5022-7. doi: 10.1016/j.vaccine.2005.05.030.
The aim of the European Sero-Epidemiology Network 2 (ESEN2) is to compare standardised serological results of vaccine preventable diseases across Europe. In order to adjust for laboratory and assay differences, the participant laboratories tested a standardisation panel for each disease and the results were plotted against those of a reference centre in order to obtain standardisation equations. We describe an algorithm for obtaining these equations which took into account outliers, censored data and model selection, and needed to be robust due to the variety of assays and diseases under investigation. If the standardisation equations explained sufficient variability, these were used to convert each country's main serum bank results to a common unitage, thereby allowing international comparisons to be made.
欧洲血清流行病学网络2（ESEN2）的目标是比较欧洲各地疫苗可预防疾病的标准化血清学结果。为了校正实验室和检测方法的差异，参与的实验室针对每种疾病检测了一个标准化样本组，并将结果与一个参考中心的结果进行比对，以获得标准化方程。我们描述了一种获取这些方程的算法，该算法考虑了异常值、截尾数据和模型选择，并且由于所研究的检测方法和疾病种类繁多而需要具备稳健性。如果标准化方程解释了足够的变异性，就用这些方程将每个国家主要血清库的结果转换为统一的单位，从而能够进行国际比较。
