Health Protection Agency, Health Protection Services, Colindale, London, UK.
Epidemiol Infect. 2012 Dec;140(12):2172-81. doi: 10.1017/S0950268812000015. Epub 2012 Jan 25.
The WHO recommends hepatitis A virus (HAV) immunization according to level of transmission and disease burden. We aimed to identify susceptible age groups by standardized serosurveys to inform HAV vaccination policy in participating countries: Belgium, Czech Republic, England, Finland, Germany, Italy, Lithuania, Malta, Romania, and Slovakia. Each country tested national serum banks (n = 1854-6748), collected during 1996-2004, for anti-HAV antibodies. Local laboratory results were standardized to common units. Forty-one per cent of those aged <30 years and 6% of those aged ≥30 years were susceptible to HAV in Romania; compared to 70-94% and 26-71%, respectively, elsewhere. Romania reported high HAV incidence in children and young adults. Other countries reported HAV disease primarily in older risk groups. The results suggest low level of HAV transmission in most of Europe. Romania, however, appeared as an area with intermediate transmission. Vaccination of risk groups in countries with high susceptibility of young and middle-aged adults needs to be continued.
世界卫生组织（WHO）根据传播水平和疾病负担建议进行甲型肝炎病毒（HAV）免疫接种。我们旨在通过标准化血清学调查确定易感年龄组，为参与国家的 HAV 疫苗接种政策提供信息：比利时、捷克共和国、英格兰、芬兰、德国、意大利、立陶宛、马耳他、罗马尼亚和斯洛伐克。每个国家都检测了本国血清库（1996-2004 年采集，n = 1854-6748）中的抗 HAV 抗体。当地实验室的结果被标准化为通用单位。在罗马尼亚，<30 岁人群中有 41%和≥30 岁人群中有 6%对 HAV 易感；而在其他国家，这一比例分别为 70-94%和 26-71%。罗马尼亚报告称，儿童和青年人群中 HAV 发病率较高。其他国家报告的 HAV 疾病主要发生在年龄较大的高危人群中。结果表明，欧洲大部分地区 HAV 传播水平较低。然而，罗马尼亚似乎是一个传播水平中等的地区。在高风险的年轻和中年人群中继续进行疫苗接种需要继续进行。
