Kasperczyk Sławomir, Birkner Ewa, Kasperczyk Aleksandra, Kasperczyk Janusz
Department of Biochemistry, Silesian Medical University in Katowice, ul. Jordana 19, 41-808 Zabrze, Poland.
Hum Exp Toxicol. 2005 Jun;24(6):287-95. doi: 10.1191/0960327105ht528oa.
The study population included healthy men and hypertensive employees of zinc and lead steelworks in the south of Poland. Workers exposed to lead (n=137) were divided into two groups: the first included employees with low exposure to lead (LL) with mean blood lead (PbB) 25-40 microg/dL and the second one with PbB over 40 microg/dL (HL group). The administration workers (n=35) were the control group. Evaluation of lipids and oxidative changes of cholesterol and lipids were estimated in blood samples. No significant changes in concentration of 7-ketocholesterol and blood lipids (cholesterol, HDL, LDL, triglycerides) were found. Lipid peroxidation (LP) was significantly higher in both exposed groups in plasma and in the HL group in erythrocytes when compared with control. There can be two independent sources of LP increase: the first is connected with the direct effect of lead's ions on erythrocytes, the second is the prooxidative effect of delta-aminolevulinic acid. Hypertension in the HL group when compared with people with PbB below 40 microg/dL (OR 4.4, 95%CI 1.4-14.5) was found more often. LP significantly increased by about 71% and concentration of 7-ketocholesterol by about 122% in hypertensives when compared with normotensives in the HL group.
研究人群包括波兰南部锌铅钢铁厂的健康男性和高血压员工。接触铅的工人（n = 137）被分为两组：第一组为低铅暴露员工（LL），平均血铅（PbB）为25 - 40微克/分升，第二组血铅超过40微克/分升（HL组）。行政人员（n = 35）为对照组。对血液样本中的脂质以及胆固醇和脂质的氧化变化进行了评估。未发现7 - 酮胆固醇和血脂（胆固醇、高密度脂蛋白、低密度脂蛋白、甘油三酯）浓度有显著变化。与对照组相比，两个暴露组血浆中的脂质过氧化（LP）显著更高，HL组红细胞中的脂质过氧化也显著更高。脂质过氧化增加可能有两个独立来源：第一个与铅离子对红细胞的直接作用有关，第二个是δ - 氨基乙酰丙酸的促氧化作用。与血铅低于40微克/分升的人相比，HL组高血压更为常见（比值比4.4，95%置信区间1.4 - 14.5）。与HL组中的血压正常者相比，高血压患者的脂质过氧化显著增加约71%，7 - 酮胆固醇浓度显著增加约122%。
