埃塞俄比亚东部哈勒尔镇修车工人的化学物质暴露情况及其在生化水平上的相关健康风险：一项对比研究
Chemical exposure in garage workers and related health risks on the biochemical levels: A comparative study in Harar town, eastern Ethiopia.
作者信息
Ataro Zerihun, Geremew Abraham, Urgessa Fekadu
机构信息
Department of Medical Laboratory Sciences, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia.
Department of Environmental Health Sciences, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia.
出版信息
SAGE Open Med. 2019 Apr 24;7:2050312119846792. doi: 10.1177/2050312119846792. eCollection 2019.
OBJECTIVES
Occupational exposure to chemicals causes a wide range of biological effects depending on the level and duration of exposure. The current study is intended to determine the differences in biochemical levels among garage workers compared with occupationally nonexposed participants in Harar town, eastern Ethiopia.
METHODS
A comparative cross-sectional study was conducted in Harar town, eastern Ethiopia. Thirty (30) garage workers were selected and compared with 30 age- and sex-matched control group of teachers and students. Demographic and occupational data were collected using a structured questionnaire by trained data collector. Biochemical levels were measured by automated clinical chemistry analyzer (Autolab 18, Boehringer-Mannheim Diagnostics, the United States). Data were analyzed using STATA Version 13.
RESULTS
All of the included garage workers were male. A statistically significant increase were found in alanine aminotransferase (35.60 ± 7.93 vs 19.17 ± 0.91 U/L; P value = 0.0440), aspartate aminotransferase (47.23 ± 4.89 vs 27.03 ± 1.13 U/L; P value = 0.0002), total protein (85.83 ± 1.16 vs 76.40 ± 0.86 g/l; P value < 0.0001), uric acid (7.34 ± 0.29 vs 5.19 ± 0.21 mg/dl; P value < 0.0001), glucose (85.13 ± 3.92 vs 75.60 ± 2.40 mg/dl; P value = 0.0425); total cholesterol (199.40 ± 13.11 vs 140.37 ± 3.81 mg/dl; P value = 0.0001) and triglyceride (143.40 ± 5.79 vs 110.60 ± 8.98 mg/dl; P value = 0.0033) in garage workers compared with control group. On the contrary, a statistically significant decrease were found in albumin (39.37 ± 1.78 vs 46.37 ± 0.56 g/l; P value = 0.0004) and urea (21.63 ± 1.04 vs 27.60 ± 1.69 mg/dl; P value = 0.0039) among garage workers compared with the control group.
CONCLUSION
Our finding indicates that working in the garage changes most of the biochemical levels. Therefore, appropriate and effective safety measures need to be implemented to prevent possible chemical exposure during routine work.
目的
职业性接触化学物质会根据接触水平和持续时间产生广泛的生物学效应。本研究旨在确定埃塞俄比亚东部哈勒尔镇的汽车修理工与非职业接触者之间生化水平的差异。
方法
在埃塞俄比亚东部的哈勒尔镇进行了一项比较性横断面研究。选取了30名汽车修理工，并与30名年龄和性别匹配的教师和学生对照组进行比较。由经过培训的数据收集员使用结构化问卷收集人口统计学和职业数据。通过自动临床化学分析仪（美国勃林格殷格翰诊断公司的Autolab 18）测量生化水平。使用STATA 13版软件进行数据分析。
结果
所有纳入的汽车修理工均为男性。与对照组相比，汽车修理工的丙氨酸转氨酶（35.60±7.93对19.17±0.91 U/L；P值=0.0440）、天冬氨酸转氨酶（47.23±4.89对27.03±1.13 U/L；P值=0.0002）、总蛋白（85.83±1.16对76.40±0.86 g/l；P值<0.0001）、尿酸（7.34±0.29对5.19±0.21 mg/dl；P值<0.0001）、葡萄糖（85.13±3.92对75.60±2.40 mg/dl；P值=0.0425）、总胆固醇（199.40±13.11对140.37±3.81 mg/dl；P值=0.0001）和甘油三酯（143.40±5.79对110.60±8.98 mg/dl；P值=0.0033）有统计学意义的升高。相反，与对照组相比，汽车修理工的白蛋白（39.37±1.78对46.37±0.56 g/l；P值=0.0004）和尿素（21.63±1.04对27.60±1.69 mg/dl；P值=0.0039）有统计学意义的降低。
结论
我们的研究结果表明，在汽车修理店工作会改变大多数生化水平。因此，需要实施适当有效的安全措施，以防止日常工作中可能的化学物质接触。
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