Grigor'eva M E, Golubeva M G
Izv Akad Nauk Ser Biol. 2005 May-Jun(3):311-5.
The effect of neuropeptide thyrotropin-releasing hormone (TRH) and its synthetic analogue digipramine on certain indices of the blood coagulation system and fibrinolysis were studied in vitro and in vivo. The peptides added to the pool of normal rat plasma at 10(-10) to 10(-3) M increased the procoagulant activity but had virtually no effect on fibrinolysis. Intravenous administration of TRH and digipramine increased the procoagulant activity of the blood and thrombocyte aggregation but decreased fibrinolysis; digipramine had a more pronounced effect on the coagulation potential of the blood and a less pronounced effect on fibrinolytic indices as compared to TRH. Intranasal administration of the peptides did not change the pattern of their effect on hemostatic indices although the effects became less pronounced.
在体外和体内研究了神经肽促甲状腺激素释放激素（TRH）及其合成类似物地吉帕明对血液凝固系统和纤维蛋白溶解某些指标的影响。以10^(-10)至10^(-3) M的浓度添加到正常大鼠血浆中的这些肽增加了促凝血活性，但对纤维蛋白溶解几乎没有影响。静脉注射TRH和地吉帕明可增加血液的促凝血活性和血小板聚集，但降低纤维蛋白溶解；与TRH相比，地吉帕明对血液凝固潜能的影响更明显，对纤维蛋白溶解指标的影响较不明显。经鼻给药这些肽并没有改变它们对止血指标的影响模式，尽管影响变得不那么明显。
