Liapina L A, Pastorova V E, Golubeva M G, Grigor'eva M G
Biology Faculty, Moscow State University, Vorob'evy Gory, Moscow, 119899 Russia.
Izv Akad Nauk Ser Biol. 2003 Sep-Oct(5):594-8.
We studied hemocoagulation properties of the amino acid glycine in vitro and after intravenous administration in animals (rats). Addition of 10(-3) and 10(-4) M glycine to the plasma increases the aggregability of thrombocytes in vitro, while all other tested concentrations had virtually no effect on hemostatic parameters of the plasma. Intravenous administration of glycine increased functional activity of the enzyme fibrinolytic unit of the anticoagulation system. Dose dependence of this effect has been established. The causes of these changes and possible application of this compound for activation of fibrinolysis are discussed.
我们在体外以及对动物（大鼠）静脉给药后研究了氨基酸甘氨酸的血液凝固特性。向血浆中添加10⁻³和10⁻⁴M的甘氨酸可在体外增加血小板的聚集性，而所有其他测试浓度对血浆的止血参数几乎没有影响。静脉注射甘氨酸可提高抗凝系统中纤维蛋白溶解单位酶的功能活性。已确定了这种作用的剂量依赖性。讨论了这些变化的原因以及该化合物在激活纤维蛋白溶解方面的可能应用。
