Sheikh J I
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, California.
Clin Geriatr Med. 1992 May;8(2):411-26.
Anxiety disorders appear to be among the most common psychiatric illnesses of the elderly. Although systematic studies of the phenomenology and treatment of anxiety disorders in the elderly are rather scant, inferences based on studies of younger patients combined with careful clinical observations can be very helpful for both diagnostic and treatment purposes. Several medical conditions can mimic anxiety disorders and suggest a need to consider a possible underlying organic condition during the process of evaluation. Clinical evaluation should be complemented by rating scales and laboratory tests where appropriate. Anxiety disorders occurring for the first time in late life appear to be milder in symptomatology than early-onset disorders. Most anxiety disorders can be well managed using the available treatments. It appears that short-acting benzodiazepines, such as oxazepam and lorazepam, are the treatment of choice for short-term symptoms of geriatric anxiety. For anxiety of longer durations (e.g., greater than 6 months), a nonbenzodiazepine such as buspirone seems preferable. Antidepressants seem effective in cases of mixed anxiety-depression or panic disorder. There is clearly a need, however, to perform more controlled clinical trials of these medications to establish empirically derived guidelines for safety, efficacy, and specificity of these drugs for the elderly population. Finally, nonpharmacologic methods such as cognitive-behavioral treatments can be very effective for the management of certain anxiety disorders, particularly phobias.
焦虑症似乎是老年人中最常见的精神疾病之一。尽管对老年人焦虑症的现象学和治疗的系统研究相当匮乏,但基于对年轻患者的研究以及仔细的临床观察所做的推断,对诊断和治疗都非常有帮助。一些躯体疾病可能会模仿焦虑症,这表明在评估过程中需要考虑是否存在潜在的器质性疾病。临床评估应在适当的时候辅以评定量表和实验室检查。晚年首次出现的焦虑症在症状学上似乎比早发性焦虑症更轻。大多数焦虑症可以通过现有的治疗方法得到很好的控制。似乎短效苯二氮䓬类药物,如奥沙西泮和劳拉西泮,是治疗老年焦虑症短期症状的首选药物。对于持续时间较长(如超过6个月)的焦虑症,非苯二氮䓬类药物如丁螺环酮似乎更可取。抗抑郁药在混合性焦虑抑郁或惊恐障碍的情况下似乎有效。然而,显然需要对这些药物进行更多的对照临床试验,以建立基于经验的针对老年人的安全性、有效性和特异性指南。最后,非药物方法,如认知行为疗法,对某些焦虑症,特别是恐惧症的管理可能非常有效。