Athanassiadou P P, Veneti S Z, Kyrkou K A, Intzes K S, Mouzaka L I, Papadimitriou G K
Cytology and Cytogenetic Department, Laiko Hospital, University of Athens, Greece.
Cancer Detect Prev. 1992;16(2):113-8.
The purpose of this study was to evaluate and correlate different high risk factors in breast cysts to produce a more accurate prognosis. We considered the cytology of the lining epithelium (apocrine or flattened), the Na+/K+ ratio (less than 3; greater than or equal to 3), the pH (lower, equal, or higher than 7.30), and the EGFr (present or not) in an attempt to reach better prognoses and diagnoses by evaluating more than one risk factor. Our material of 40 macrocysts consisted of 23 simple cysts with flattened epithelium and 17 complex cysts with apocrine or hyperplastic epithelium. In the simple cysts, the Na+/K+ ratio was greater than or equal to 3, while in the complex cysts the Na+/K+ ratio was, in all cases but one, less than 3. The pH was not significantly lower than neutral in the complex cysts. The EGFr was detected in 5 of 23 simple cysts and in 12 of 17 complex cysts. In conclusion, reaction of EGFr in smears of cyst fluids with the low intracystic electrolyte ratios may provide an explanation of why women with apocrine metaplasia or epithelial hyperplasia may be at higher risk of breast cancer than women with cysts which are lined by flattened epithelium.
本研究的目的是评估乳腺囊肿的不同高危因素并建立关联，以得出更准确的预后情况。我们考虑了内衬上皮细胞的细胞学特征（大汗腺型或扁平型）、钠钾比（小于3；大于或等于3）、pH值（低于、等于或高于7.30）以及表皮生长因子受体（EGFr）的情况（存在或不存在），试图通过评估多个危险因素来获得更好的预后和诊断。我们选取了40个大囊肿作为研究材料，其中包括23个内衬扁平上皮的单纯性囊肿和17个内衬大汗腺或增生上皮的复杂性囊肿。在单纯性囊肿中，钠钾比大于或等于3，而在复杂性囊肿中，除1例外，所有囊肿的钠钾比均小于3。复杂性囊肿的pH值并不显著低于中性。在23个单纯性囊肿中有5个检测到EGFr，在17个复杂性囊肿中有12个检测到EGFr。总之，囊肿液涂片里EGFr的反应以及囊内低电解质比例，或许可以解释为什么大汗腺化生或上皮增生的女性患乳腺癌的风险可能高于内衬扁平上皮囊肿的女性。
