Vizoso F, Fueyo A, Allende M T, Fernández J, García-Morán M, Ruibal A
Surgery Service, Hospital General de Asturias, Oviedo, Spain.
Eur J Surg Oncol. 1990 Jun;16(3):209-14.
Breast cyst fluids were aspirated during the mild luteal phase of the menstrual cycle from 88 patients with gross cystic disease. According to intracystic Na+/K+ ratio three categories of cyst were identified: Type I with low Na+/K+ ratio, low levels of chloride, glucose, and pH, and high concentrations of dehydroepiandrosterone-sulphate (DHAS) and apocrine epithelium; Type II with high Na+/K+ ratio presenting levels of chloride, glucose, pH, and DHAS similar to those found in plasma, and flattened epithelium; Type III with intermediate values for the above parameters. The findings suggest that the cysts could correspond to the different functional stages of the epithelium lining the cysts. Cyst classification was evaluated using a discriminant analysis, which allows breast cyst fluids to be assigned within a category defined by the Na+/K+ ratio. The apparent correct rate for each category was more than 87%. The variables that better discriminate among groups of cysts were chloride, glucose, intracystic prolactin, and pH, respectively. These discriminant functions could be used as criteria for an optimal classification of breast cysts, which might help study of the epidemiology of breast cancer and its relationship to gross cystic disease.
在月经周期的黄体期轻度阶段，从88例患有乳腺大囊性病的患者中抽取乳腺囊肿液。根据囊内钠钾比，确定了三类囊肿：I型囊肿钠钾比低，氯化物、葡萄糖和pH值水平低，硫酸脱氢表雄酮（DHAS）和大汗腺上皮浓度高；II型囊肿钠钾比高，氯化物、葡萄糖、pH值和DHAS水平与血浆中相似，上皮扁平；III型囊肿上述参数为中间值。研究结果表明，这些囊肿可能对应于囊肿内衬上皮的不同功能阶段。使用判别分析对囊肿分类进行评估，该分析可将乳腺囊肿液归入由钠钾比定义的类别中。每个类别的明显正确分类率超过87%。能更好地区分囊肿组别的变量分别是氯化物、葡萄糖、囊内催乳素和pH值。这些判别函数可作为乳腺囊肿最佳分类的标准，这可能有助于研究乳腺癌的流行病学及其与乳腺大囊性病的关系。
