用于生物材料设计的蛋白质工程方法。

Protein engineering approaches to biomaterials design.

作者信息

Maskarinec Stacey A, Tirrell David A

机构信息

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.

出版信息

Curr Opin Biotechnol. 2005 Aug;16(4):422-6. doi: 10.1016/j.copbio.2005.06.009.

DOI:10.1016/j.copbio.2005.06.009

PMID:16006115

Abstract

Biomaterials play crucial roles in reconstructive surgery, tissue engineering and regenerative medicine. Protein engineering offers powerful solutions to the challenges posed by the creation of well-defined, multifunctional materials that guide cell and tissue behavior. Especially challenging is the complex interplay between mechanical and biological properties in determining the success or failure of biomaterials designed for clinical use.

摘要

生物材料在重建手术、组织工程和再生医学中发挥着关键作用。蛋白质工程为创建能够引导细胞和组织行为的明确、多功能材料所带来的挑战提供了强有力的解决方案。尤其具有挑战性的是，在确定用于临床的生物材料的成败时，机械性能和生物学性能之间存在复杂的相互作用。