Sermesant M, Rhode K, Sanchez-Ortiz G I, Camara O, Andriantsimiavona R, Hegde S, Rueckert D, Lambiase P, Bucknall C, Rosenthal E, Delingette H, Hill D L G, Ayache N, Razavi R
Cardiac MR Research Group, King's College London, 5th Floor Thomas Guy House, Guy's Hospital, London, UK.
Med Image Anal. 2005 Oct;9(5):467-80. doi: 10.1016/j.media.2005.05.003.
Simulating cardiac electromechanical activity is of great interest for a better understanding of pathologies and for therapy planning. Design and validation of such models is difficult due to the lack of clinical data. XMR systems are a new type of interventional facility in which patients can be rapidly transferred between X-ray and MR systems. Our goal is to design and validate an electromechanical model of the myocardium using XMR imaging. The proposed model is computationally fast and uses clinically observable parameters. We present the integration of anatomy, electrophysiology, and motion from patient data. Pathologies are introduced in the model and simulations are compared to measured data. Initial qualitative comparison on the two clinical cases presented is encouraging. Once fully validated, these models will make it possible to simulate different interventional strategies.
模拟心脏机电活动对于更好地理解病理状况和进行治疗规划具有重要意义。由于缺乏临床数据，此类模型的设计和验证颇具难度。XMR系统是一种新型介入设备，患者可在X射线和磁共振系统之间快速转移。我们的目标是利用XMR成像设计并验证心肌的机电模型。所提出的模型计算速度快，并使用临床可观察参数。我们展示了如何将来自患者数据的解剖结构、电生理学和运动进行整合。在模型中引入病理状况，并将模拟结果与测量数据进行比较。对所呈现的两个临床病例的初步定性比较结果令人鼓舞。一旦得到充分验证，这些模型将能够模拟不同的介入策略。
