Seo David, Ginsburg Geoffrey S
Center for Genomic Medicine, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, NC 27710, USA.
Curr Opin Chem Biol. 2005 Aug;9(4):381-6. doi: 10.1016/j.cbpa.2005.06.009.
An important by-product of sequencing the human genome has been the development of a novel 'toolbox' for biomarker discovery and development. Genomic medicine is an emerging discipline in the genome sciences that integrates these tools to interrogate genomic variation in well-defined populations in order to develop predictors of disease susceptibility, progression and drug response. Several important classes of biomarkers result from these analyses which, when translated to clinical medicine and drug development, will have an important impact on human health and disease. This review highlights both the opportunities and challenges in bringing biomarkers into clinical medicine.
对人类基因组进行测序的一个重要副产品是开发了一个用于生物标志物发现和开发的新型“工具箱”。基因组医学是基因组科学中一门新兴学科，它整合这些工具以研究明确人群中的基因组变异，从而开发疾病易感性、进展和药物反应的预测指标。这些分析产生了几类重要的生物标志物，当转化应用于临床医学和药物开发时，将对人类健康和疾病产生重要影响。本综述重点介绍了将生物标志物引入临床医学所面临的机遇和挑战。
