Moore Rowan E, Kirwan Jennifer, Doherty Mary K, Whitfield Phillip D
Proteomics and Functional Genomics Research Group, Faculty of Veterinary Science, University of Liverpool, Liverpool, United Kingdom.
Biomark Insights. 2007 Jul 10;2:185-96.
The causes of many important diseases in animals are complex and multifactorial, which present unique challenges. Biomarkers indicate the presence or extent of a biological process, which is directly linked to the clinical manifestations and outcome of a particular disease. Identifying biomarkers or biomarker profiles will be an important step towards disease characterization and management of disease in animals. The emergence of post-genomic technologies has led to the development of strategies aimed at identifying specific and sensitive biomarkers from the thousands of molecules present in a tissue or biological fluid. This review will summarize the current developments in biomarker discovery and will focus on the role of transcriptomics, proteomics and metabolomics in biomarker discovery for animal health and disease.
动物中许多重要疾病的病因复杂且具有多因素性，这带来了独特的挑战。生物标志物表明生物过程的存在或程度，这与特定疾病的临床表现和结果直接相关。识别生物标志物或生物标志物谱将是朝着动物疾病特征描述和疾病管理迈出的重要一步。后基因组技术的出现促使了旨在从组织或生物流体中存在的数千种分子中识别特定且敏感的生物标志物的策略的发展。本综述将总结生物标志物发现的当前进展，并将重点关注转录组学、蛋白质组学和代谢组学在动物健康和疾病生物标志物发现中的作用。
