López Peña M, Muñoz F, Alemañ N, González A, Pereira J L, Nieto J M
Anatomía Patológica, Facultad de Veterinaria, Campus Universitario, Lugo E-27002, Spain.
Vet Pathol. 2005 Jul;42(4):489-91. doi: 10.1354/vp.42-4-489.
A 6-month-old female German Shepherd Dog died as a result of profuse oral bleeding. At postmortem examination, the oral cavity showed visible roots of the right mandibular fourth premolar and first molar teeth and, in addition, they were very mobile and compressible. Radiographs showed a generalized radiolucency in the body of the right mandible, with evidence of resorption of the affected alveolar bone. Histologically, the lesion of the right mandible was characterized by the lysis of bony structures and a non-malignant proliferation of blood-filled vascular spaces lined by a single layer of well-differentiated endothelial cells. The clinical, radiographic, and histologic presentation of this dog is consistent with that associated with Gorham-Stout disease, a rare bone disorder in humans.
一只6个月大的雌性德国牧羊犬因口腔大量出血死亡。尸检时，口腔可见右下颌第四前磨牙和第一磨牙的牙根，此外，这些牙齿非常松动且可压缩。X光片显示右下颌骨体普遍呈透射性，有患侧牙槽骨吸收的迹象。组织学上，右下颌骨病变的特征是骨结构溶解，以及由单层高分化内皮细胞衬里的充满血液的血管腔的非恶性增生。这只狗的临床、X光和组织学表现与人类罕见的骨疾病——戈勒姆-斯托特病相符。
