Gu S, Ducas J, Patton J N, Greenberg D, Prewitt R M
Department of Medicine, University of Manitoba, Winnipeg, Canada.
Chest. 1992 Jun;101(6):1684-90. doi: 10.1378/chest.101.6.1684.
We employed a canine model of coronary thrombosis, induced by injection of radioactive blood clot, via a catheter placed in the left anterior descending coronary artery, to compare effects of intracoronary administration of recombinant tissue plasminogen activator (rtPA) and urokinase (UK) on rate and extent of coronary thrombolysis. Two doses of UK, 15,000 U/kg (UK15) and 30,000 U/kg (UK30) and two doses of rtPA, 0.25 mg/kg (rtPA.25) and 0.75 mg/kg (rtPA.75) were given. Drugs were infused over 45 min. Compared with the other regimens, rate and extent of coronary thrombolysis were significantly increased with rtPA.75. Also, despite a much higher dose of UK, coronary thrombolysis was similar with UK30 and rtPA.25. Compared with UK15, rate and extent of coronary thrombolysis were increased with rtPA.25. These results indicate that intracoronary administration of rtPA is superior to intracoronary UK in inducing thrombolysis.
我们采用了一种冠状动脉血栓形成的犬类模型，通过将放射性血凝块经置于左前降支冠状动脉的导管注入来诱导血栓形成，以比较冠状动脉内给予重组组织型纤溶酶原激活剂（rtPA）和尿激酶（UK）对冠状动脉溶栓速率和程度的影响。给予了两种剂量的UK，即15,000 U/kg（UK15）和30,000 U/kg（UK30），以及两种剂量的rtPA，即0.25 mg/kg（rtPA.25）和0.75 mg/kg（rtPA.75）。药物在45分钟内输注。与其他方案相比，rtPA.75使冠状动脉溶栓的速率和程度显著增加。此外，尽管UK的剂量高得多，但UK30和rtPA.25的冠状动脉溶栓效果相似。与UK15相比，rtPA.25使冠状动脉溶栓的速率和程度增加。这些结果表明，冠状动脉内给予rtPA在诱导溶栓方面优于冠状动脉内给予UK。
