Gu S A, Ducas J, Wolfe K, Patton J N, Prewitt R M
Section of Cardiology, University of Manitoba, Winnipeg, Canada.
Chest. 1991 Jul;100(1):201-6. doi: 10.1378/chest.100.1.201.
We employed a canine model of coronary thrombosis, induced by injection of radioactive blood clot, via a catheter placed in the left anterior descending coronary artery, to compare effects of recombinant tissue plasminogen activator (rtPA) administered intravenously and administered directly into the coronary circulation. A control group did not receive rtPA. Compared with controls, both rtPA regimens induced coronary thrombolysis. However, compared with intravenous administration, rate and extent of coronary thrombolysis were increased with intracoronary administration. Most likely, the enhanced thrombolysis with intracoronary administration is explained by an increase in delivery of the drug to the thrombus.
我们采用了一种冠状动脉血栓形成的犬类模型，通过将放射性血凝块经置于左前降支冠状动脉的导管注入来诱导血栓形成，以比较静脉注射重组组织型纤溶酶原激活剂（rtPA）和直接注入冠状动脉循环的效果。对照组未接受rtPA治疗。与对照组相比，两种rtPA给药方案均能诱导冠状动脉血栓溶解。然而，与静脉给药相比，冠状动脉内给药的血栓溶解速度和程度有所增加。冠状动脉内给药时溶栓效果增强很可能是由于药物向血栓的递送增加所致。
