Prewitt R M, Gu S, Schick U, Ducas J
Department of Medicine, University of Mannitoba, Winnipeg, Canada.
Angiology. 1994 Aug;45(8):687-94. doi: 10.1177/000331979404500803.
The authors employed a canine model of coronary thrombosis, induced by injection of radioactive blood clot, via a catheter placed in the left anterior descending (LAD) coronary artery, to compare effects of different rates of administration of recombinant tissue plasminogen activator (rtPA) on efficacy of coronary thrombolysis. In one group of dogs 0.75 mg/kg of rtPA was administered via the catheter placed in the LAD coronary artery over fifteen minutes. In a second group of dogs the same dose of rtPA was administered over forty-five minutes. Compared with the group in which the drug was administered over forty-five minutes, by thirty and forty-five minutes after onset of treatment, the extent of coronary thrombolysis was significantly greater (P < 0.05) in the group who received the drug over fifteen minutes. These results demonstrate that the rate of intracoronary administration of rtPA may significantly affect thrombolytic efficacy.
作者采用了一种冠状动脉血栓形成的犬类模型，通过将放射性血凝块注射到置于左前降支（LAD）冠状动脉的导管内来诱导血栓形成，以比较重组组织型纤溶酶原激活剂（rtPA）不同给药速率对冠状动脉溶栓疗效的影响。在一组犬中，将0.75mg/kg的rtPA通过置于LAD冠状动脉的导管在15分钟内给药。在第二组犬中，相同剂量的rtPA在45分钟内给药。与药物在45分钟内给药的组相比，在治疗开始后30分钟和45分钟时，在15分钟内接受药物治疗的组冠状动脉溶栓程度明显更大（P<0.05）。这些结果表明，rtPA冠状动脉内给药速率可能显著影响溶栓疗效。
