来自锡兰毛霉（Trichopus zeylanicus Gaerten）酒精提取物的糖肽脂质部分的适应原活性（第二部分）。

Adaptogenic activity of glyco-peptido-lipid fraction from the alcoholic extract of Trichopus zeylanicus Gaerten (part II).

作者信息

Singh B, Chandan B K, Sharma N, Singh S, Khajuria A, Gupta D K

机构信息

Department of Pharmacology, Regional Research Laboratory, Canal Road, Jammu--Tawi, India.

出版信息

Phytomedicine. 2005 Jun;12(6-7):468-81. doi: 10.1016/j.phymed.2005.01.009.

DOI:10.1016/j.phymed.2005.01.009

PMID:16008124

Abstract

Anti-stress activity was carried out on glyco-peptido-lipid (AF) fraction from the alcoholic extract of Trichopus zeylanicus Gaerten and demonstrated against a battery of tests in rats and mice. AF exhibited significant anti-stress activity in dose-related manners in all the parameters studied against different models used to induce non-specific stress viz physical and chemically. The major parameters studied were immobilization induced gastric ulceration, adjuvant-induced trauma (Stress); humoral antibody synthesis in normal and immuno-suppressed mice and delayed type of hypersensitivity (DTH) reaction, chemically stress-induced alteration in hepatic function and anti-oxidant activity. The extract of Withania somnifera root (a commercial preparation available locally, Dabur India ltd.) was used to compare the results. In the safety evaluation study the maximum tolerance dose (MTD) and oral LD50 were found to be more than 3000 mg/kg, with no signs of abnormalities or any mortality observed for 15 days period under observation after single dose of drug administration. Feeding behaviour and fecal output were normal.

摘要

对来自锡兰毛霉酒精提取物的糖肽脂质（AF）部分进行了抗应激活性研究，并在大鼠和小鼠的一系列试验中得到证实。在针对用于诱导非特异性应激的不同模型（即物理和化学模型）所研究的所有参数中，AF均以剂量相关的方式表现出显著的抗应激活性。所研究的主要参数包括固定诱导的胃溃疡、佐剂诱导的创伤（应激）；正常和免疫抑制小鼠的体液抗体合成以及迟发型超敏反应（DTH）；化学应激诱导的肝功能改变和抗氧化活性。使用印度当地商业制剂印度达布尔有限公司的睡茄根提取物来比较结果。在安全性评估研究中，最大耐受剂量（MTD）和口服LD50均超过3000 mg/kg，单次给药后观察15天期间未观察到异常迹象或任何死亡情况。摄食行为和粪便排出量正常。