Schoof Heiko, Spannagl Manuel, Yang Li, Ernst Rebecca, Gundlach Heidrun, Haase Dirk, Haberer Georg, Mayer Klaus F X
Technische Universität München, Chair of Genome Oriented Bioinformatics, Center of Life and Food Science, D-85354 Freising-Weihenstephan, Germany.
Plant Physiol. 2005 Jul;138(3):1301-9. doi: 10.1104/pp.104.059188.
With several plant genomes sequenced, the power of comparative genome analysis can now be applied. However, genome-scale cross-species analyses are limited by the effort for data integration. To develop an integrated cross-species plant genome resource, we maintain comprehensive databases for model plant genomes, including Arabidopsis (Arabidopsis thaliana), maize (Zea mays), Medicago truncatula, and rice (Oryza sativa). Integration of data and resources is emphasized, both in house as well as with external partners and databases. Manual curation and state-of-the-art bioinformatic analysis are combined to achieve quality data. Easy access to the data is provided through Web interfaces and visualization tools, bulk downloads, and Web services for application-level access. This allows a consistent view of the model plant genomes for comparative and evolutionary studies, the transfer of knowledge between species, and the integration with functional genomics data.
随着多个植物基因组被测序，现在可以应用比较基因组分析的力量。然而，基因组规模的跨物种分析受到数据整合工作的限制。为了开发一个整合的跨物种植物基因组资源，我们维护了用于模式植物基因组的综合数据库，包括拟南芥（Arabidopsis thaliana）、玉米（Zea mays）、蒺藜苜蓿（Medicago truncatula）和水稻（Oryza sativa）。强调了数据和资源的整合，包括内部以及与外部合作伙伴和数据库的整合。结合人工整理和最先进的生物信息学分析以获得高质量数据。通过网络界面和可视化工具、批量下载以及用于应用程序级访问的网络服务，提供对数据的便捷访问。这使得在比较和进化研究中能够对模式植物基因组有一致的认识，实现物种间的知识转移，并与功能基因组学数据进行整合。
