Güldener U, Münsterkötter M, Kastenmüller G, Strack N, van Helden J, Lemer C, Richelles J, Wodak S J, García-Martínez J, Pérez-Ortín J E, Michael H, Kaps A, Talla E, Dujon B, André B, Souciet J L, De Montigny J, Bon E, Gaillardin C, Mewes H W
Institute for Bioinformatics, GSF National Research Center for Environment and Health, Ingolstädter Landstrasse 1, D-85764 Neuherberg, Germany.
Nucleic Acids Res. 2005 Jan 1;33(Database issue):D364-8. doi: 10.1093/nar/gki053.
The Comprehensive Yeast Genome Database (CYGD) compiles a comprehensive data resource for information on the cellular functions of the yeast Saccharomyces cerevisiae and related species, chosen as the best understood model organism for eukaryotes. The database serves as a common resource generated by a European consortium, going beyond the provision of sequence information and functional annotations on individual genes and proteins. In addition, it provides information on the physical and functional interactions among proteins as well as other genetic elements. These cellular networks include metabolic and regulatory pathways, signal transduction and transport processes as well as co-regulated gene clusters. As more yeast genomes are published, their annotation becomes greatly facilitated using S.cerevisiae as a reference. CYGD provides a way of exploring related genomes with the aid of the S.cerevisiae genome as a backbone and SIMAP, the Similarity Matrix of Proteins. The comprehensive resource is available under http://mips.gsf.de/genre/proj/yeast/.
全面酵母基因组数据库(CYGD)汇编了关于酿酒酵母及相关物种细胞功能信息的全面数据资源,酿酒酵母被选为真核生物中理解最透彻的模式生物。该数据库是一个由欧洲联盟生成的通用资源,超越了提供单个基因和蛋白质的序列信息及功能注释。此外,它还提供有关蛋白质以及其他遗传元件之间物理和功能相互作用的信息。这些细胞网络包括代谢和调节途径、信号转导和运输过程以及共同调节的基因簇。随着更多酵母基因组的发表,以酿酒酵母作为参考极大地促进了它们的注释。CYGD提供了一种借助酿酒酵母基因组作为主干以及蛋白质相似性矩阵SIMAP来探索相关基因组的方法。该全面资源可在http://mips.gsf.de/genre/proj/yeast/获取。