铱催化的与阴离子型N-亲核试剂的高对映选择性烯丙基胺化反应
Highly enantioselective iridium-catalysed allylic aminations with anionic N-nucleophiles.
作者信息
Weihofen Robert, Dahnz Axel, Tverskoy Olena, Helmchen Günter
机构信息
Organisch-Chemisches Institut der Ruprecht-Karls-Universität Heidelberg, Im Neuenheimer Feld 270, 69207 Heidelberg, Germany.
出版信息
Chem Commun (Camb). 2005 Jul 28(28):3541-3. doi: 10.1039/b505197e. Epub 2005 Jun 9.
DOI:10.1039/b505197e
PMID:16010317
Abstract
Iridium-catalysed allylic substitutions with anionic N-nucleophiles were achieved with regioselectivity of up to 49:1 and enantiomeric excess of up to 98%.
摘要
铱催化的带有阴离子N-亲核试剂的烯丙基取代反应实现了高达49:1的区域选择性和高达98%的对映体过量。
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