5-羟色胺1A受体激活大鼠腹内侧下丘脑神经元中的钾离子电导。
5-HT1A receptors activate a potassium conductance in rat ventromedial hypothalamic neurones.
作者信息
Newberry N R
机构信息
Merck, Sharp & Dohme Research Laboratories, Neuroscience Research Centre, Harlow, Essex, U.K.
出版信息
Eur J Pharmacol. 1992 Jan 14;210(2):209-12. doi: 10.1016/0014-2999(92)90673-r.
The extracellularly recorded firing rate of rat ventromedial hypothalamic neurones in vitro was inhibited by 5-hydroxytryptamine (5-HT), 5-carboxamidotryptamine (5-CT), 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) and buspirone, 2-methyl-5-HT was relatively ineffective. At 1 microM, spiperone and cyanopindolol antagonised the 5-CT induced inhibition, MDL 72222 (10 microM) and ketanserin (1 microM) did not. Intracellular recordings with voltage-clamp revealed that 5-HT and 5-CT evoked a tetrodotoxin-resistant outward current with a reversal potential of ca. -100 mV. 5-HT1A receptors likely activate a potassium conductance on these neurones.
体外记录的大鼠腹内侧下丘脑神经元的放电频率受到5-羟色胺（5-HT）、5-羧基胺基色胺（5-CT）、8-羟基-2-（二正丙基氨基）四氢萘（8-OH-DPAT）和丁螺环酮的抑制，而2-甲基-5-HT的作用相对较弱。在1微摩尔浓度时，螺哌隆和氰吲哚洛尔可拮抗5-CT诱导的抑制作用，MDL 72222（10微摩尔）和酮色林（1微摩尔）则无此作用。电压钳细胞内记录显示，5-HT和5-CT可诱发一种对河豚毒素不敏感的外向电流，其反转电位约为-100毫伏。5-HT1A受体可能激活这些神经元上的钾电导。
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