一种5-羟色胺1样受体介导百日咳毒素敏感的体外大鼠腹内侧下丘脑神经元抑制作用。
A 5-HT1-like receptor mediates a pertussis toxin-sensitive inhibition of rat ventromedial hypothalamic neurones in vitro.
作者信息
Newberry N R, Priestley T
机构信息
Merck Sharp and Dohme Research Laboratories, Harlow, Essex.
出版信息
Br J Pharmacol. 1988 Sep;95(1):6-8. doi: 10.1111/j.1476-5381.1988.tb16541.x.
Abstract
5-Hydroxytryptamine (5-HT), 5-carboxamidotryptamine and 8-hydroxy-2-(di-n-propylamino)-tetralin inhibited rat ventromedial hypothalamic neurones in vitro in a concentration-dependent manner. The agonist-induced inhibition was reduced by spiperone (1 microM) and by pertussis toxin , but not by MDL 72222 (10 microM) or ketanserin (1 microM). The inhibition appeared to be mediated via 5-HT1A-receptors and a pertussis toxin-sensitive pathway.
摘要
5-羟色胺（5-HT）、5-羧酰胺色胺和8-羟基-2-（二正丙基氨基）-四氢萘在体外以浓度依赖性方式抑制大鼠腹内侧下丘脑神经元。激动剂诱导的抑制作用被舒必利（1微摩尔）和百日咳毒素降低，但未被MDL 72222（10微摩尔）或酮色林（1微摩尔）降低。这种抑制作用似乎是通过5-HT1A受体和一条对百日咳毒素敏感的途径介导的。
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