Webberley M J, Webberley J M, Newell D G, Lowe P, Melikian V
Dudley Road Hospital, Birmingham.
Epidemiol Infect. 1992 Jun;108(3):457-62. doi: 10.1017/s0950268800049967.
An enzyme-linked immunosorbent assay has been used to diagnose serologically the prevalence of Helicobacter pylori infection in Asian life-long vegans. There was no difference in the seropositivity between these individuals and a group of age- and sex-matched Asian meat-eaters, indicating the meat consumption is not a risk factor for H. pylori infection. However, both Asian groups had a higher prevalence of infection than age- and sex-matched Caucasian meat-eaters. Additionally, the Asian individuals had a wider range of specific IgG antibody concentrations than the Caucasians. This did not appear to be due to antigenic cross-reactivity between H. pylori and Campylobacter jejuni. The significance of these observations to the establishment of cut-off levels for the serodiagnosis of certain ethnic groups is discussed.
酶联免疫吸附测定已用于血清学诊断亚洲终身素食者中幽门螺杆菌感染的流行情况。这些个体与一组年龄和性别匹配的亚洲肉食者之间的血清阳性率没有差异，这表明肉类消费不是幽门螺杆菌感染的危险因素。然而，这两个亚洲群体的感染率均高于年龄和性别匹配的白种人肉食者。此外，亚洲个体的特异性IgG抗体浓度范围比白种人更广。这似乎不是由于幽门螺杆菌和空肠弯曲菌之间的抗原交叉反应所致。讨论了这些观察结果对确定某些种族群体血清学诊断临界值的意义。
