Kato Yoshitake, Ohyama Takako, Mita Hajime, Yamamoto Yasuhiko
Department of Chemistry, University of Tsukuba, Tsukuba 305-8571, Japan.
J Am Chem Soc. 2005 Jul 20;127(28):9980-1. doi: 10.1021/ja050191b.
Parallel G-quadruplexes formed from oligonucleotide sequences, d(TTAGn), where n = 3-5, have been shown to form a dimer through end-to-end stacking of 3'-terminal G-tetrads. The monomers and dimers of the G-quadruplexes are in dynamic equilibrium with an exchange rate of approximately 1 s-1. A thermodynamic study demonstrated that the dimerization of the G-quadruplexes is largely enthalpic in origin.
由寡核苷酸序列d(TTAGn)（其中n = 3 - 5）形成的平行G-四链体已被证明通过3'-末端G-四联体的端对端堆积形成二聚体。G-四链体的单体和二聚体处于动态平衡，交换速率约为1 s-1。一项热力学研究表明，G-四链体的二聚化在很大程度上源于焓变。
