Ikegami S, Kajiyama N, Ozaki Y, Myotoishi Y, Miyashiro S, Takayama S, Kobayashi M, Kitagawa I
Department of Applied Biochemistry, Hiroshima University, Japan.
FEBS Lett. 1992 May 18;302(3):284-6. doi: 10.1016/0014-5793(92)80460-x.
Halenaquinol sulfate, a hydroquinone sulfate obtained from the sponge Xestospongia sapra, prevented cell membrane fusion events of echinaderm gametes but did not affect early embryonic development of fertilized eggs up to the gastrula stage. However, halenaquinol sulfate inhibited secretion of hatching enzyme, resulting in the formation of gastrulae that were surrounded by the fertilization envelope. Therefore, the use of halenaquinol sulfate offers a unique opportunity to analyze the role of secretory events in complex populations of cells without affecting other cellular functions.
硫酸卤萘醌是一种从海绵Xestospongia sapra中获得的对苯二酚硫酸盐，它能阻止棘皮动物配子的细胞膜融合事件，但不影响受精卵直至原肠胚阶段的早期胚胎发育。然而，硫酸卤萘醌会抑制孵化酶的分泌，导致形成被受精膜包围的原肠胚。因此，硫酸卤萘醌的使用为分析复杂细胞群体中分泌事件的作用提供了一个独特的机会，而不会影响其他细胞功能。
