Morissette Sandra Baker, Palfai Tibor P, Gulliver Suzy Bird, Spiegel David A, Barlow David H
Center for Anxiety and Related Disorders, Boston University, MA, USA.
Psychol Addict Behav. 2005 Jun;19(2):192-8. doi: 10.1037/0893-164X.19.2.192.
In a 2 (patch) x 2 (smoking) x 2 (anxiety) mixed design, 52 undergraduate smokers randomly received a nicotine (21 mg) or placebo patch. After a 4-hr nicotine absorption/deprivation period, participants imagined several scenarios varying in cue content: (a) anxiety plus smoking, (b) anxiety, (c) smoking, and (d) neutral. Although smoking urge increased in both the nicotine and placebo conditions after the absorption/deprivation period, those who received the placebo reported significantly greater urge. During the cue reactivity trials, a significant Patch x Smoking x Anxiety interaction effect was observed for urge. However, participants who received nicotine still experienced moderate urges, indicating that nicotine did not attenuate cue-elicited urge. Transdermal nicotine did not diminish anxiety during the absorption/deprivation period or in response to the cues.
在一项2(贴片)×2(吸烟)×2(焦虑)的混合设计中,52名本科吸烟者被随机分配接受尼古丁(21毫克)贴片或安慰剂贴片。在4小时的尼古丁吸收/戒断期后,参与者想象了几种线索内容不同的情景:(a)焦虑加吸烟,(b)焦虑,(c)吸烟,以及(d)中性。尽管在吸收/戒断期后,尼古丁组和安慰剂组的吸烟冲动都有所增加,但服用安慰剂的参与者报告的冲动明显更强。在线索反应性试验中,观察到贴片×吸烟×焦虑对冲动有显著的交互作用。然而,接受尼古丁的参与者仍然有中度冲动,这表明尼古丁并没有减弱线索引发的冲动。透皮尼古丁在吸收/戒断期或对线索的反应中并没有减轻焦虑。