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伤残调整生命年:一种确定公共卫生优先事项的工具?

[Disability-adjusted life years: an instrument for defining public health priorities?].

作者信息

Granados D, Lefranc A, Reiter R, Grémy I, Spira A

机构信息

Service de Santé publique et d'Epidémiologie, Atelier Parisien de Santé Publique, CHU Bicêtre, 78, rue du Général-Leclerc, 94275 Le Kremlin-Bicêtre Cedex.

出版信息

Rev Epidemiol Sante Publique. 2005 Apr;53(2):111-25. doi: 10.1016/s0398-7620(05)84582-1.

Abstract

BACKGROUND

The objective of this paper is the study of a health indicator allowing surveillance and evaluation of the overall health of the Paris population, and providing information to help prioritize possible choices among preventive and curative actions. Moreover, comparison between results obtained for Paris with a global health indicator, "Disability-adjusted life years" (DALYs) and available bibliographical data will enable clarifying some points about summary measures of health.

METHODS

The method used is that of the Global Burden of Disease. It allows a ranking of diseases using an indicator called DALYs. This indicator integrates mortality and morbidity components by summing expected years of life lost due to premature mortality and calculated years of healthy life lost. DALYs were calculated using local mortality data and published regional disabilities tables from the World Health Organisation (WHO).

RESULTS

There were a total of 242 061 DALYs for Paris for the year 1999. The six leading specific causes are: alcoholic psychosis and dependence (accounting for 6.5% of the total), lung cancers (5.7%), ischaemic hearth disease (4.8%), depression (4.4%), dementias (4.2%), and arthritis (3.9%). Men contributed the majority of DALYs for the first three. For four of the six leading causes, the majority of DALYs came from years lived with disability, rather than mortality. Only for lung cancer and ischaemic hearth disease was the majority of DALYs from years of life lost by mortality.

CONCLUSION

The results for Paris are used to illustrate how DALYs can illuminate debates about public health priorities. Such data can inform the population about health condition and provide decision makers with global health indicators. The next step will be to estimate the DALYs from local morbidity data when available, and compare these results to those based on the World Health Organisation tables, which are not sensitive to local results other than those due to mortality. Future steps include further evaluation and development of this method for surveillance, assessment and evaluation of public health actions. However, some of the results obtained with this indicator underline the limits of this kind of analysis.

摘要

背景

本文的目的是研究一种健康指标,用于监测和评估巴黎人口的整体健康状况,并提供信息以帮助在预防和治疗行动中对可能的选择进行优先排序。此外,将巴黎的结果与全球健康指标“伤残调整生命年”(DALYs)以及现有文献数据进行比较,将有助于阐明有关健康汇总指标的一些问题。

方法

所采用的方法是全球疾病负担研究方法。它使用一种名为DALYs的指标对疾病进行排名。该指标通过将因过早死亡导致的预期寿命损失年数与计算得出的健康生命损失年数相加,整合了死亡率和发病率两个组成部分。DALYs是使用当地死亡率数据和世界卫生组织(WHO)公布的区域残疾表计算得出的。

结果

1999年巴黎的DALYs总数为242,061。六大主要具体病因是:酒精性精神病和酒精依赖(占总数的6.5%)、肺癌(5.7%)、缺血性心脏病(4.8%)、抑郁症(4.4%)、痴呆症(4.2%)和关节炎(3.9%)。男性在上述前三种病因导致的DALYs中占多数。在六大主要病因中的四种病因中,大部分DALYs来自残疾生存年数,而非死亡年数。只有肺癌和缺血性心脏病的大部分DALYs来自因死亡导致的寿命损失年数。

结论

巴黎的结果用于说明DALYs如何能够阐明有关公共卫生优先事项的辩论。此类数据可以让民众了解健康状况,并为决策者提供全球健康指标。下一步将是在有可用的当地发病率数据时估计DALYs,并将这些结果与基于世界卫生组织表格得出的结果进行比较,后者除了因死亡率导致的结果外,对当地结果不敏感。未来的步骤包括进一步评估和开发这种用于监测、评估和评价公共卫生行动的方法。然而,用该指标获得的一些结果凸显了这种分析方法的局限性。

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