Jaton-Ogay K, Suter M, Crameri R, Falchetto R, Fatih A, Monod M
Laboratoire de mycologie, Centre hospitalier universitaire vaudois, Lausanne, Switzerland.
FEMS Microbiol Lett. 1992 Apr 15;71(2):163-8. doi: 10.1016/0378-1097(92)90506-j.
An Aspergillus fumigatus extracellular alkaline protease (ALP) which is an enzyme of the subtilisin family is a potential virulent factor of the fungus. The gene encoding ALP was isolated from a genomic library made from DNA of an A. fumigatus isolate. The nucleotide sequence of this gene was compared to that of a cDNA encoding A. oryzae ALP and to that of a cDNA from A. fumigatus encoding the mature ALP protein. Mature A. fumigatus ALP contains 282 amino acids and is encoded by three exons. The pre-proenzyme has a leader sequence of 121 amino acids.
