Chiarioni Giuseppe, Salandini Lara, Whitehead William E
Divisione di Riabilitazione Gastroenterologica, Universitá di Verona, Azienda Ospedaliera di Verone, Centro Ospedaliero Clinicizzato, Valeggio sul Mincio, Verona, Italy.
Gastroenterology. 2005 Jul;129(1):86-97. doi: 10.1053/j.gastro.2005.05.015.
BACKGROUND & AIMS: Biofeedback is reported to be as effective for slow transit constipation as for pelvic floor dyssynergia and no more effective than education. We aimed to test the hypothesis that biofeedback benefits only patients with pelvic floor dyssynergia, describe the physiologic mechanism of treatment, and identify predictors of success.
Fifty-two patients (49 women; average age, 35 years), all with delayed whole gut transit, included 34 with pelvic floor dyssynergia, 12 with slow transit only, and 6 who met only 1 of 2 criteria for pelvic floor dyssynergia. All received 5 weekly biofeedback sessions directed at increasing rectal pressure and relaxing pelvic floor muscles during straining plus practice defecating a balloon. Patients were retested by questionnaire; symptom diary; balloon defecation; transit study at 1, 6, 12, and 24 months; and anorectal manometry at 1 and 6 months.
At 6 months, greater improvements were seen in pelvic floor dyssynergia compared with slow transit only; 71% versus 8% reported satisfaction ( P = .001), and 76% versus 8% reported >/=3 bowel movements per week ( P < .001). Improvements were maintained at 24 months of follow-up. Biofeedback eliminated dyssynergia in 91% and enabled 85% to defecate the balloon. Satisfaction was correlated with improved ability to defecate the balloon (rho = .73; P < .001), reductions in dyssynergia (rho = .69; P < .001), and increased rectal pressure during straining (rho = .36; P < .01). Success was predicted by pelvic floor dyssynergia, milder constipation, and less frequent abdominal pain at baseline.
Biofeedback is an effective treatment for pelvic floor dyssynergia but not slow transit constipation.
据报道,生物反馈疗法对慢传输型便秘的治疗效果与盆底失协调型便秘相同,且并不比健康教育更有效。我们旨在验证以下假设:生物反馈仅对盆底失协调型便秘患者有益,描述其治疗的生理机制,并确定成功的预测因素。
52例患者(49例女性;平均年龄35岁),均存在全肠道传输延迟,其中34例为盆底失协调型便秘,12例仅为慢传输型便秘,6例仅符合盆底失协调型便秘两项标准中的一项。所有患者均接受为期5周的生物反馈治疗,旨在增加排便时直肠压力并放松盆底肌肉,同时练习排出气囊。通过问卷调查、症状日记、气囊排便测试、在1、6、12和24个月时进行传输研究以及在1和6个月时进行肛肠测压对患者进行重新测试。
在6个月时,与仅慢传输型便秘相比,盆底失协调型便秘患者的改善更为明显;71%的盆底失协调型便秘患者与8%的慢传输型便秘患者表示满意(P = 0.001),76%的盆底失协调型便秘患者与8%的慢传输型便秘患者报告每周排便≥3次(P < 0.001)。在24个月的随访中,改善情况得以维持。生物反馈消除了91%的失协调现象,并使85%的患者能够排出气囊。满意度与排出气囊能力的改善(rho = 0.73;P < 0.001)、失协调现象的减轻(rho = 0.69;P < 0.001)以及排便时直肠压力的增加(rho = 0.36;P < 0.01)相关。成功的预测因素为盆底失协调型便秘、便秘程度较轻以及基线时腹痛频率较低。
生物反馈是治疗盆底失协调型便秘的有效方法,但对慢传输型便秘无效。