Li Xiaoqin, Lei Qiang, Xie Jiao, Li Fang, Liu Jing, Chen Yuelai, Mao Qiangjian
Clinical Medicine College, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, China.
Acupuncture and Moxibustion Massage College, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, China.
Front Psychiatry. 2025 Jun 18;16:1607297. doi: 10.3389/fpsyt.2025.1607297. eCollection 2025.
BACKGROUND: Although the phenomenon of functional constipation (FC) that accompanies anxiety or depression has been extensively investigated worldwide, no bibliometric studies are available in this regard. This study therefore aimed to analyze the current status and extent of research and areas of interest in the study of FC with anxiety or depression. METHODS: Data from studies on FC with anxiety or depression, that were performed between 2003 and 2024, were retrieved from the Web of Science Core Collection database. Data regarding the annual number of publications, authors, countries, and references were assessed using CiteSpace v6.3.R1 (64-bit) and Microsoft Excel, and those pertaining to keywords and cited authors were evaluated using VOSviewer 1.6.20. The co-occurrence and clustering functions were then used to generate visual knowledge maps. RESULTS: The overall annual publication volume demonstrated an upward trend between 2003 and 2024; this was indicative of promising research prospects. The 427 publications identified included 6 types of papers, among which original research articles represented the highest proportion (357 [83.61%] articles published across 200 journals). had the highest publication volume (30 articles, 7.02%). The United States of America had published most of the papers (135 articles, 31.61%) on the topic. Harvard University was the research institution with the most published papers (21 articles, 4.92%), and Michel Bouchoucha had authored the highest number of articles (13 articles, 3.04%). CONCLUSION: Future studies in the field of basic medicine need to determine the etiology and pathogenesis of FC with anxiety or depression; in particular, they need to evaluate the role of opioid drugs as a key etiological factor. The role played by the brain-gut axis also warrants investigation. From the clinical perspective, studies need to focus on evidence-based medicine; particular emphasis needs to be placed on randomized double-blind controlled trials with stringent quality control, high-quality meta-analyses, and evaluation of questionnaires and scales. Treatment techniques need to be explored in greater detail; in this context, it is recommended that fecal microbiota transplantation and biofeedback therapy are adopted in the clinic. Furthermore, Patients with FC, especially those with a history of anxiety or depression, tend to have overlapping dyspepsia symptoms.
背景:尽管功能性便秘(FC)伴焦虑或抑郁的现象在全球范围内已得到广泛研究,但目前尚无关于此方面的文献计量学研究。因此,本研究旨在分析FC伴焦虑或抑郁研究的现状、研究范围及研究热点领域。 方法:从Web of Science核心合集数据库中检索2003年至2024年间进行的FC伴焦虑或抑郁的研究数据。使用CiteSpace v6.3.R1(64位)和Microsoft Excel评估每年的出版物数量、作者、国家和参考文献等数据,使用VOSviewer 1.6.20评估关键词和被引作者相关数据。然后利用共现和聚类功能生成可视化知识图谱。 结果:2003年至2024年间,总体年出版物量呈上升趋势,这表明该领域具有良好的研究前景。共识别出427篇出版物,包括6种类型的论文,其中原创研究文章占比最高(200种期刊共发表357篇[83.61%])。 发表量最高(30篇,占7.02%)。美国发表的关于该主题的论文最多(135篇,占31.61%),哈佛大学是发表论文最多的研究机构(21篇,占4.92%),Michel Bouchoucha撰写的文章数量最多(13篇,占3.04%)。 结论:基础医学领域未来的研究需要确定FC伴焦虑或抑郁的病因和发病机制;特别是需要评估阿片类药物作为关键病因因素的作用。脑 - 肠轴所起的作用也值得研究。从临床角度来看,研究需要聚焦于循证医学;尤其应重视具有严格质量控制的随机双盲对照试验、高质量的荟萃分析以及问卷和量表评估。需要更详细地探索治疗技术;在此背景下,建议临床采用粪便微生物群移植和生物反馈疗法。此外,FC患者,尤其是有焦虑或抑郁病史的患者,往往伴有重叠的消化不良症状。
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