Zhukova T P, Sorokina E G, Popandopulo Iu G
Vopr Med Khim. 1979 Nov-Dec;25(6):676-83.
Effect of intranatal hypoxia on content of adenylic nucleotides, glycogen, lactic acid as well as on activity of ATP-ases and concentration of free amino acids was studied in rat brain tissue at various periods of postnatal development (I day-5 months). Acute hypoxia was accompanied by a decrease in content of adenylic nucleotides and glycogen, by an increase in concentration of lactic acid and by a decrease in activity of ATP-ases. During the subsequent periods, in brain tissue of animals, subjected to hypoxia, posthypoxic activation of energy metabolism was found, which depended apparently on the decreased intensity of plastic processes during the phase of active growth and of neurone differentiation. Content of the essential amino acids, actively participating in protein synthesis, was increased but concentration of nonessential amino acids was decreased at this step. The subsequent decrease in content of macroergic compounds, increase in concentration of lactic acid and inorganic phosphate as well as the decrease in activity of ATP-ases were observed in 1.5-2 months old experimental animals. The biochemical and mophological data suggest that intranatal hypoxia is responsible for irreversible impairments in developing brain.
研究了出生时缺氧对出生后不同发育阶段（出生1天至5个月）大鼠脑组织中腺苷酸、糖原、乳酸含量以及ATP酶活性和游离氨基酸浓度的影响。急性缺氧伴随着腺苷酸和糖原含量的降低、乳酸浓度的升高以及ATP酶活性的降低。在随后的时期，在经历缺氧的动物脑组织中发现了缺氧后能量代谢的激活，这显然取决于活跃生长和神经元分化阶段塑性过程强度的降低。在此阶段，积极参与蛋白质合成的必需氨基酸含量增加，但非必需氨基酸浓度降低。在1.5至2个月大的实验动物中观察到高能化合物含量随后降低、乳酸和无机磷酸盐浓度升高以及ATP酶活性降低。生化和形态学数据表明，出生时缺氧是发育中大脑不可逆损伤的原因。
