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[宫内缺氧后大鼠脑组织不同蛋白质组分中标记氨基酸掺入情况的变化]

[Changes in the incorporation of labeled amino acids into separate protein fractions of the cerebral tissue in rats after intrauterine hypoxia].

作者信息

Uvarova T M

出版信息

Biull Eksp Biol Med. 1990 Oct;110(10):351-2.

PMID:2279079
Abstract

Incorporation of 14C-amino acid mixture into the cortex and cerebellum protein was studied in 7, 15, 30 days old rats after prenatal hypoxia. Prenatal hypoxic rats was shown to have alteration of the pattern of incorporation of label predecessors into brain protein. Prenatal hypoxia led to significant decrease of incorporation value at 30,000 molecular weight fractions. It is assumed that prenatal hypoxia results in selective changes of the brain protein synthesis.

摘要

在产前缺氧后的7日龄、15日龄和30日龄大鼠中,研究了14C - 氨基酸混合物掺入皮质和小脑蛋白质的情况。结果显示,产前缺氧的大鼠将标记前体掺入脑蛋白的模式发生了改变。产前缺氧导致分子量为30000的组分掺入值显著降低。据推测,产前缺氧导致脑蛋白合成发生选择性变化。

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