Narayan K
Peter MacCallum Cancer Centre, Melbourne, Australia.
Int J Gynecol Cancer. 2005 Jul-Aug;15(4):573-82. doi: 10.1111/j.1525-1438.2005.00128.x.
FIGO staging of cervical cancer is based on anatomic compartmental spread of cervical cancer. This was necessary in the evaluation of surgical resectability in each patient. Even if the surgical resection was not deemed satisfactory, surgical findings and subsequent accurate anatomic pathology findings could be used to prescribe tailored adjuvant therapies. Recently, the management of cervical cancer has been influenced by the evidence from several surgical-pathologic studies and phase II and III combined modality treatment trials. However, the patient selection criteria used in these clinical studies were almost always refined by modern medical imaging and surgical techniques not prescribed in the FIGO staging system. The results obtained from these studies would not correlate with those from the patient population similarly treated but selected strictly along the FIGO staging criteria. This selective, heterogenous, and arbitrary refinement of FIGO staging has certainly given insight into cervical cancer biology but in the process has rendered the current FIGO staging of this disease quite inadequate. Prior knowledge of these factors through modern imaging in these patients could be used in staging and selecting the optimum treatment modality while minimizing the treatment-related morbidity. A magnetic resonance imaging-assisted FIGO staging system for cervical cancer as proposed here could be used for selecting patients appropriately for a given treatment package.
宫颈癌的国际妇产科联盟(FIGO)分期基于宫颈癌的解剖学分区扩散情况。这对于评估每位患者的手术可切除性很有必要。即便手术切除效果不理想,手术发现及后续准确的解剖病理学发现也可用于制定个性化的辅助治疗方案。近来,宫颈癌的治疗受到多项外科病理研究以及II期和III期综合治疗试验证据的影响。然而,这些临床研究中使用的患者选择标准几乎总是通过FIGO分期系统未规定的现代医学成像和外科技术进行优化。从这些研究中获得的结果与按照FIGO分期标准严格选择的、接受类似治疗的患者群体的结果不相关。FIGO分期这种有选择性的、异质性的和随意的优化确实为了解宫颈癌生物学提供了见解,但在此过程中,使得目前该疾病的FIGO分期相当不完善。通过现代成像技术事先了解这些患者的这些因素,可用于分期和选择最佳治疗方式,同时将治疗相关的发病率降至最低。本文提出的磁共振成像辅助的FIGO宫颈癌分期系统可用于为特定治疗方案适当选择患者。