Macglashan Donald
The Johns Hopkins Asthma and Allergy Center, 5501 Bayview Circle, Baltimore, MD 21224, USA.
Ann N Y Acad Sci. 2005 Jun;1050:73-88. doi: 10.1196/annals.1313.009.
A central feature of allergic reactions is the aggregation of the high-affinity IgE receptor, FcepsilonRI, to initiate a change in the behavior of the cell expressing the receptor. It is now clear that a number of cell types can express this receptor, which broadens the biology that revolves around IgE antibody. It is also quite clear that the presence of monomeric IgE antibody alters the expression of FcepsilonRI. There remains considerable uncertainty about the importance of independent regulation of the FcepsilonRIbeta subunit or its splice variant beta(T), in terms of regulating both expression and function of FcepsilonRI. There is also only primitive understanding of the role of various polymorphisms in the subunit genes on the atopic phenotype. There are, however, many efforts being made to resolve these issues and to discover other factors that regulate expression of this receptor. Of particular interest for understanding the variation in expression in atopy among patients, the role of this receptor on non-mast cell/basophils will be important to elucidate.
过敏反应的一个核心特征是高亲和力IgE受体FcepsilonRI聚集，从而引发表达该受体的细胞行为发生变化。现在很清楚，多种细胞类型都可以表达这种受体，这拓宽了围绕IgE抗体的生物学范畴。同样清楚的是，单体IgE抗体的存在会改变FcepsilonRI的表达。就调节FcepsilonRI的表达和功能而言，FcepsilonRIβ亚基或其剪接变体β(T)的独立调节的重要性仍存在很大不确定性。对于亚基基因中各种多态性在特应性表型上的作用，也只有初步的认识。然而，目前正在做出许多努力来解决这些问题，并发现其他调节该受体表达的因素。对于理解患者特应性中表达的差异而言，该受体在非肥大细胞/嗜碱性粒细胞上的作用将是阐明的关键。
