Macfarlane G J, Palmer B, Roy D, Afzal C, Silman A J, O'Neill T
Aberdeen Pain Research (Epidemiology) Group, Department of Public Health, School of Medicine, Polwarth Building Foresterhill, Aberdeen AB25 2ZD, Scotland.
Ann Rheum Dis. 2005 Aug;64(8):1217-9. doi: 10.1136/ard.2004.032656.
Anecdotal reports from rheumatologists in the United Kingdom suggest that patients from South Asian backgrounds are more likely to report widespread body pain.
To confirm the presence of an excess of widespread pain in South Asians, and to evaluate the relationship of their symptoms with levels of 25-OH vitamin D.
Two population studies involving over 3135 subjects were carried out in the North West and Midlands areas of England.
The first study confirmed an excess of widespread pain among South Asians (OR = 1.6, 95% CI 1.3 to 2.1). The second smaller study conducted only among young women also showed a similar excess of widespread pain among South Asians (OR = 1.8, 95% CI 0.7 to 4.7) and found that low levels of 25-OH vitamin D (<10 ng/ml) were more common among those with widespread pain (OR = 3.5, 95% CI 0.4 to 31.0).
Owing to the small numbers, the relationship between 25-OH vitamin D and widespread pain must be considered preliminary and requires further investigation. However, it may be one potentially treatable cause of widespread pain.
英国风湿病学家的轶事报告表明，南亚背景的患者更有可能报告全身疼痛。
确认南亚人群中普遍存在的疼痛，并评估其症状与25-羟基维生素D水平之间的关系。
在英格兰西北部和中部地区进行了两项涉及3135多名受试者的人群研究。
第一项研究证实南亚人群中普遍存在的疼痛过多（比值比=1.6，95%可信区间1.3至2.1）。第二项仅在年轻女性中进行的规模较小的研究也显示，南亚人群中普遍存在的疼痛过多（比值比=1.8，95%可信区间0.7至4.7），并发现25-羟基维生素D水平低（<10纳克/毫升）在全身疼痛患者中更为常见（比值比=3.5，95%可信区间0.4至31.0）。
由于样本数量较少，25-羟基维生素D与全身疼痛之间的关系必须被视为初步的，需要进一步研究。然而，它可能是全身疼痛的一个潜在可治疗原因。
