Department of Nutrition and Metabolism, Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey, GU2 7XH, UK.
Osteoporos Int. 2013 Feb;24(2):477-88. doi: 10.1007/s00198-012-1973-2. Epub 2012 Apr 14.
This is the first 1-year longitudinal study which assesses vitamin D deficiency in young UK-dwelling South Asian women. The findings are that vitamin D deficiency is extremely common in this group of women and that it persists all year around, representing a significant public health concern.
There is a lack of longitudinal data assessing seasonal variation in vitamin D status in young South Asian women living in northern latitudes. Studies of postmenopausal South Asian women suggest a lack of seasonal change in 25-hydroxy vitamin D [25(OH)D], although it is unclear whether this is prevalent among premenopausal South Asians. We aimed to evaluate, longitudinally, seasonal changes in 25(OH)D and prevalence of vitamin D deficiency in young UK-dwelling South Asian women as compared with Caucasians. We also aimed to establish the relative contributions of dietary vitamin D and sun exposure in explaining serum 25(OH)D.
This is a 1-year prospective cohort study assessing South Asian (n = 35) and Caucasian (n = 105) premenopausal women living in Surrey, UK (51° N), aged 20-55 years. The main outcome measured was serum 25(OH)D concentration. Secondary outcomes were serum parathyroid hormone, self-reported dietary vitamin D intake and UVB exposure by personal dosimetry.
Serum 25(OH)D <25 nmol/L was highly prevalent in South Asians in the winter (81 %) and autumn (79.2 %). Deficient status (below 50 nmol/L) was common in Caucasian women. Multi-level modelling suggested that, in comparison to sun exposure (1.59, 95 %CI = 0.83-2.35), dietary intake of vitamin D had no impact on 25(OH)D levels (-0.08, 95 %CI = -1.39 to 1.23).
Year-round vitamin D deficiency was extremely common in South Asian women. These findings pose great health threats regarding the adverse effects of vitamin D deficiency in pregnancy and warrant urgent vitamin D public health policy and action.
这是第一项评估英国居住的南亚年轻女性维生素 D 缺乏的为期 1 年的纵向研究。研究结果表明，该组女性维生素 D 缺乏非常普遍，且全年持续存在，这是一个重大的公共卫生问题。
目前缺乏评估居住在北纬地区的年轻南亚女性维生素 D 状态季节性变化的纵向数据。对绝经后南亚女性的研究表明 25-羟维生素 D [25(OH)D] 缺乏没有季节性变化，尽管尚不清楚这种情况是否在绝经前南亚女性中普遍存在。我们旨在纵向评估英国居住的年轻南亚女性与白种人相比，25(OH)D 的季节性变化以及维生素 D 缺乏症的患病率。我们还旨在确定饮食维生素 D 和阳光暴露在解释血清 25(OH)D 中的相对贡献。
这是一项为期 1 年的前瞻性队列研究，评估了英国萨里（51°N）居住的南亚（n=35）和白种人（n=105）绝经前女性，年龄在 20-55 岁之间。主要测量结果是血清 25(OH)D 浓度。次要结果是血清甲状旁腺激素、自我报告的饮食维生素 D 摄入量和通过个人剂量计测量的 UVB 暴露。
在冬季（81%）和秋季（79.2%），南亚人的血清 25(OH)D<25nmol/L 非常普遍。白种女性的维生素 D 缺乏症（<50nmol/L）较为常见。多层次建模表明，与阳光暴露（1.59，95%CI=0.83-2.35）相比，维生素 D 的饮食摄入量对 25(OH)D 水平没有影响（-0.08，95%CI=-1.39 至 1.23）。
南亚女性全年普遍存在维生素 D 缺乏症。这些发现对维生素 D 缺乏症在妊娠期间的不良影响构成了巨大的健康威胁，需要紧急制定维生素 D 公共卫生政策和采取行动。
