Ioannidis John P A, Bernstein Jonine, Boffetta Paolo, Danesh John, Dolan Siobhan, Hartge Patricia, Hunter David, Inskip Peter, Jarvelin Marjo-Riitta, Little Julian, Maraganore Demetrius M, Bishop Julia A Newton, O'Brien Thomas R, Petersen Gloria, Riboli Elio, Seminara Daniela, Taioli Emanuela, Uitterlinden André G, Vineis Paolo, Winn Deborah M, Salanti Georgia, Higgins Julian P T, Khoury Muin J
Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece.
Am J Epidemiol. 2005 Aug 15;162(4):302-4. doi: 10.1093/aje/kwi201. Epub 2005 Jul 13.
The task of identifying genetic determinants for complex, multigenetic diseases is hampered by small studies, publication and reporting biases, and lack of common standards worldwide. The authors propose the creation of a network of networks that include groups of investigators collecting data for human genome epidemiology research. Twenty-three networks of investigators addressing specific diseases or research topics and representing several hundreds of teams have already joined this initiative. For each field, the authors are currently creating a core registry of teams already participating in the respective network. A wider international registry will include all other teams also working in the same field. Independent investigators are invited to join the registries and existing networks and to join forces in creating additional ones as needed. The network of networks aims to register these networks, teams, and investigators; be a resource for information about or connections to the many networks; offer methodological support; promote sound design and standardization of analytical practices; generate inclusive overviews of fields at large; facilitate rapid confirmation of findings; and avoid duplication of effort.
针对复杂多基因疾病确定遗传决定因素的任务，受到研究规模小、发表和报告偏倚以及全球缺乏通用标准的阻碍。作者提议创建一个网络联盟，其中包括为人类基因组流行病学研究收集数据的研究人员小组。23个针对特定疾病或研究主题、代表数百个团队的研究人员网络已经加入了该倡议。对于每个领域，作者目前正在创建已经参与各自网络的团队核心注册表。一个更广泛的国际注册表将包括所有其他在同一领域工作的团队。邀请独立研究人员加入注册表和现有网络，并根据需要联合起来创建更多网络。网络联盟旨在登记这些网络、团队和研究人员；成为有关众多网络的信息资源或连接渠道；提供方法学支持；促进分析实践的合理设计和标准化；对整个领域进行全面概述；便于快速确认研究结果；并避免工作重复。
