Dagna Lorenzo, Broccolo Francesco, Paties Carlo T, Ferrarini Marina, Sarmati Loredana, Praderio Luisa, Sabbadini Maria Grazia, Lusso Paolo, Malnati Mauro S
Università Vita-Salute San Raffaele School of Medicine, Milan, Italy.
N Engl J Med. 2005 Jul 14;353(2):156-63. doi: 10.1056/NEJMoa042850.
We describe an immunocompetent 61-year-old woman who was negative for human immunodeficiency virus and who had recurrent human herpesvirus 8 (HHV-8) infection associated with a relapsing systemic inflammatory syndrome characterized by fever, lymphadenopathy, splenomegaly, edema, arthrosynovitis, and rash. Kaposi's sarcoma developed 10 months after the initial clinical presentation. A correlation was documented between the recurrent clinical manifestations and the HHV-8 load in plasma and peripheral-blood mononuclear cells. Histologic examination of an enlarged lymph node heavily infected with HHV-8 revealed an atypical lymphoproliferative disorder characterized by paracortical hyperplasia and collapsed primary and secondary follicles.
我们描述了一名61岁免疫功能正常的女性，其人类免疫缺陷病毒检测呈阴性，患有复发性人类疱疹病毒8型（HHV-8）感染，并伴有以发热、淋巴结病、脾肿大、水肿、关节滑膜炎和皮疹为特征的复发性全身炎症综合征。卡波西肉瘤在首次临床表现出现10个月后发生。血浆和外周血单核细胞中的HHV-8载量与复发性临床表现之间存在相关性。对一个被HHV-8严重感染的肿大淋巴结进行组织学检查，发现了一种非典型淋巴细胞增殖性疾病，其特征为副皮质增生以及初级和次级滤泡塌陷。
