Beitz Janice M
WOCNEP School of Nursing, La Salle University, Philadelphia, PA 19141, UAS.
Ostomy Wound Manage. 2005 Jun;51(6):52-4, 56-8.
Heparin-induced thrombocytopenia syndrome is a serious, potentially life-threatening adverse reaction to the use of heparin anticoagulation therapy that can result in significant skin damage and organ morbidity. A case study design is used to describe the innovative use of a topical wound treatment (trypsin-balsam of Peru-castor oil ointment) on bullous lesions related to the effects of this syndrome. An elderly, morbidly obese woman was treated for 2 weeks with twice-daily applications of the product along with non-adherent oil emulsion dressings. Oozing decreased substantially within a few days and open blisters closed within 1 week. After 2 weeks of therapy, the bullous skin reaction was fully resolved with no recurrence. The results of this case study suggest that this topical product may have had a positive effect on the bullous lesions and should be considered for use in other similar significant integumentary reactions.
肝素诱导的血小板减少综合征是使用肝素抗凝治疗时一种严重的、可能危及生命的不良反应，可导致严重的皮肤损伤和器官病变。本病例研究旨在描述一种局部伤口治疗方法（秘鲁香脂 - 蓖麻油胰蛋白酶软膏）在与该综合征相关的大疱性病变上的创新应用。一名老年、病态肥胖女性接受了为期2周的治疗，每天两次涂抹该产品，并使用不粘连油乳剂敷料。几天后渗液大幅减少，开放性水疱在1周内愈合。经过2周治疗，大疱性皮肤反应完全消退，无复发。该病例研究结果表明，这种局部产品可能对大疱性病变有积极作用，应考虑用于其他类似的严重皮肤反应。
