Khokhar Sudarshan, Natung Tanie, Sony Parul, Sharma Namrata, Agarwal Nutan, Vajpayee Rasik B
Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, India.
Cornea. 2005 Aug;24(6):654-60. doi: 10.1097/01.ico.0000153102.19776.80.
This study was designed to compare and evaluate the efficacy of amniotic membrane transplantation with the conventional management (tarsorrhaphy and bandage contact lens) in eyes with refractory neurotrophic corneal ulcers.
Thirty eyes of 30 patients (14 females and 16 males) with neurotrophic corneal ulcers refractory to medical management were included and divided randomly into group 1 (n = 15), who received conventional management with a tarsorrhaphy (n = 11) or bandage contact lens (n = 4), and group 2 (n = 15), who underwent Amniotic Membrane Transplantation. The outcome parameters evaluated were epithelialization time, duration of healing of corneal ulcers, and improvement in best corrected visual acuity.
The mean age in our study was 37 +/- 14.71 years. At the end of 3 months follow-up, 10 of 15 patients (66.67%) in group 1 showed complete epithelialization and subsequent healing and 11 of 15 patients (73.33%) in group 2 showed complete epithelialization and healing (P > 0.05). The median time for complete epithelialization was 21 days in both groups. Both groups showed an improvement in the best-corrected visual acuity.
Both amniotic membrane transplantation and conventional management (tarsorrhaphy or bandage contact lens) are effective treatment modalities for refractory neurotrophic corneal ulcers.
本研究旨在比较和评估羊膜移植术与传统治疗方法（睑裂缝合术和绷带式隐形眼镜）在治疗难治性神经营养性角膜溃疡眼中的疗效。
纳入30例（14例女性，16例男性）药物治疗无效的神经营养性角膜溃疡患者的30只眼，随机分为第1组（n = 15），接受睑裂缝合术（n = 11）或绷带式隐形眼镜（n = 4）的传统治疗；第2组（n = 15），接受羊膜移植术。评估的结果参数包括上皮化时间、角膜溃疡愈合时间以及最佳矫正视力的改善情况。
本研究中患者的平均年龄为37±14.71岁。随访3个月结束时，第1组15例患者中有10例（66.67%）显示完全上皮化并随后愈合，第2组15例患者中有11例（73.33%）显示完全上皮化并愈合（P>0.05）。两组完全上皮化的中位时间均为21天。两组的最佳矫正视力均有改善。
羊膜移植术和传统治疗方法（睑裂缝合术或绷带式隐形眼镜）都是治疗难治性神经营养性角膜溃疡的有效治疗方式。
