Schomäker K, Hientzsch B, Franke W G, Scheidhauer K, Scharl A, Jantsch K, Shukla S K, Limouris G, Schicha H
Klinik und Poliklinik für Nuklearmedizin, Universität zu Köln.
Nuklearmedizin. 1995 Feb;34(1):32-9.
Differences of yttrium biokinetics after application to male tumor-bearing mice of 87Y-citrate were studied in comparison to a 87Y-NTA-EDTMP-Ca mixture after variation of both the manner of application (intraperitoneal vs. intratumoral) and the tumor type (mamma carcinoma vs. melanoma). The application of 87Y as NTA-EDTMP-Ca preparation led--in comparison to the citrate form applied so far--to a similar radionuclide tumor accumulation and distinctly lower extratumoral radioactivities in liver, spleen and skeleton with clearly more favorable tumor/background ratios. Melanomas showed a significantly higher radioactivity accumulation (factor 2-3) after injection of 87Y-NTA-EDTMP-Ca than mamma carcinomas. Intratumoral application led to high initial radioactivities in the tumors. Radioactivity concentrations which are comparable with those after intraperitoneal application were achieved within 4 h after intratumoral application. The application of the EDTMP-containing mixture promises in comparison to the traditional citrate form higher radiation doses in the tumor related to the whole-body radiation exposure. The consequences for a possible tumor therapy will be further investigated.
将87Y-柠檬酸盐应用于雄性荷瘤小鼠后，研究了钇生物动力学的差异，并与87Y-NTA-EDTMP-Ca混合物进行了比较，比较了给药方式（腹腔内给药与瘤内给药）和肿瘤类型（乳腺癌与黑色素瘤）的变化。与迄今为止应用的柠檬酸盐形式相比，以NTA-EDTMP-Ca制剂形式应用87Y导致类似的放射性核素肿瘤蓄积，并且肝脏、脾脏和骨骼中的瘤外放射性明显降低，肿瘤/背景比明显更有利。黑色素瘤在注射87Y-NTA-EDTMP-Ca后显示出比乳腺癌明显更高的放射性蓄积（2-3倍）。瘤内给药导致肿瘤内的初始放射性较高。瘤内给药后4小时内达到了与腹腔内给药相当的放射性浓度。与传统的柠檬酸盐形式相比，含EDTMP的混合物应用有望在与全身辐射暴露相关的肿瘤中提供更高的辐射剂量。对可能的肿瘤治疗的影响将进一步研究。
