Bleicher J M, Lacko A G
Department of Medicine, Texas College of Osteopathic Medicine, Fort Worth 76107-2690.
J Am Osteopath Assoc. 1992 May;92(5):625-32.
Low levels of high-density lipoproteins have been consistently shown to be a major risk factor for coronary heart disease. However, the precise role of HDL in the prevention or reversal of atherosclerosis (or both) is unknown. It has been proposed that HDL functions jointly with the enzyme lecithin:cholesterol acyltransferase and the cholesteryl ester transfer protein to facilitate the movement of cholesterol from tissues to the liver. This mechanism--referred to as reverse cholesterol transport--has been shown to be an important physiologic mechanism. However, its clinical significance, though intriguing, is unclear. This article reviews recent advances concerning the components of reverse cholesterol transport and evaluates their potential significance in the early diagnosis and treatment of atherosclerosis.
一直以来，低密度脂蛋白水平低被证明是冠心病的主要危险因素。然而，高密度脂蛋白在预防或逆转动脉粥样硬化（或两者兼具）方面的确切作用尚不清楚。有人提出，高密度脂蛋白与卵磷脂胆固醇酰基转移酶和胆固醇酯转运蛋白共同发挥作用，以促进胆固醇从组织向肝脏的转运。这种机制——被称为逆向胆固醇转运——已被证明是一种重要的生理机制。然而，其临床意义尽管引人关注，但仍不明确。本文综述了逆向胆固醇转运各成分的最新进展，并评估了它们在动脉粥样硬化早期诊断和治疗中的潜在意义。
