卵母细胞捐赠周期中的临床反应、卵母细胞数量与成功率之间的关系。
The relationship of clinical response, oocyte number, and success in oocyte donor cycles.
作者信息
Letterie Gerard, Marshall Lorna, Angle Marlane
机构信息
Center for Fertility and Reproductive Endocrinology, Virginia Mason Medical Center, Seattle, Washington, USA.
出版信息
J Assist Reprod Genet. 2005 Mar;22(3):115-7. doi: 10.1007/s10815-005-4875-9.
PURPOSE
The purpose of the study was to determine if there is a threshold of clinical response to ovarian stimulation below which pregnancy rates diminish in oocyte donation cycles.
METHODS
Two hundred and seventy-six oocyte donor cycles were reviewed. Data were stratified by number of oocytes retrieved and divided into pregnant versus non-pregnant outcomes.
RESULTS
There were no differences in fertilization rates or clinical pregnancy rates regardless of the number of oocytes retrieved ranging from 3 to > 25. There was no difference in the mean age of the donors in pregnant versus non-pregnant cycles.
CONCLUSIONS
These data suggest that a lower threshold below which cycle cancellation should be considered donation cycles is different than standard IVF.
目的
本研究的目的是确定在卵母细胞捐赠周期中，是否存在一个临床反应阈值，低于该阈值妊娠率会降低。
方法
回顾了276个卵母细胞捐赠周期。数据按回收的卵母细胞数量分层，并分为妊娠与未妊娠结局。
结果
无论回收的卵母细胞数量在3至>25个之间，受精率或临床妊娠率均无差异。妊娠周期与未妊娠周期的供者平均年龄无差异。
结论
这些数据表明，低于该阈值应考虑取消周期的卵母细胞捐赠周期的较低阈值与标准体外受精不同。
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