Padmanabhapillai Ajayan, Porjesz Bernice, Ranganathan Mohini, Jones Kevin A, Chorlian David B, Tang Yongqiang, Kamarajan Chella, Rangaswamy Madhavi, Stimus Arthur, Begleiter Henri
Department of Psychiatry, Neurodynamics Laboratory, SUNY Health Science Center, Brooklyn, NY, USA.
Int J Psychophysiol. 2006 Apr;60(1):15-26. doi: 10.1016/j.ijpsycho.2005.03.026. Epub 2005 Jul 12.
We investigated the early evoked gamma frequency band activity in alcoholics (n=122) and normal controls (n=72) during a visual oddball task. A time-frequency representation method was applied to EEG data in order to obtain phase-locked gamma band activity (29-45 Hz) and was analyzed within a 0-150 ms time window range. Significant reduction of the gamma band response in the frontal region during target stimulus processing was observed in alcoholic compared to control subjects. In contrast, significantly higher gamma band response for the non-target stimulus was observed in alcoholics compared to controls. It is suggested that the reduction in early evoked frontal gamma band response to targets may be associated with frontal lobe dysfunction commonly observed in alcoholics. This perhaps can be characterized by a deficient top-down processing mechanism.
我们在一项视觉Oddball任务中研究了酗酒者（n = 122）和正常对照组（n = 72）早期诱发的伽马频段活动。为了获得锁相伽马频段活动（29 - 45赫兹），将一种时频表示方法应用于脑电图数据，并在0 - 150毫秒的时间窗口范围内进行分析。与对照组相比，在酗酒者中观察到在目标刺激处理期间额叶区域伽马频段反应显著降低。相反，与对照组相比，在酗酒者中观察到对非目标刺激的伽马频段反应显著更高。提示对目标的早期诱发额叶伽马频段反应降低可能与酗酒者中常见的额叶功能障碍有关。这可能表现为自上而下处理机制的缺陷。
