Karadağ Erdener, Uzüm Omer Bariş, Saraydin Dursun, Güven Olgun
Adnan Menderes University, Fen-Edebiyat Faculty, Department of Chemistry, 09010 Aydin, Turkey.
Int J Pharm. 2005 Sep 14;301(1-2):102-11. doi: 10.1016/j.ijpharm.2005.05.026.
The aim of this study was to investigate the equilibrium swelling properties in urea solutions of gamma-radiation induced polyelectrolyte copolymeric hydrogels consisting of acrylamide (AAm) and crotonic acid (CA). Poly(acrylamide-co-crotonic acid), poly(AAm-co-CA) hydrogels containing different amounts of CA were obtained in the form of rods after radiation. Swelling experiments were performed in aqueous urea solutions at 25 degrees C, gravimetrically. The hydrogels showed large extents of swelling in aqueous (urea/water) media the swelling being highly dependent on the chemical composition of the hydrogels and irradiation dose. The percentage swelling of poly(AAm-co-CA) hydrogels was between 1160 and 4250%, while that of the AAm hydrogels was between 670 and 900%. The diffusional exponent values (n) are between 0.51 and 0.66, hence the diffusion of urea/water into the hydrogels is non-Fickian. Equilibrium urea/water contents of the hydrogel systems were changed between 0.870 and 0.977.
本研究旨在探究由丙烯酰胺（AAm）和巴豆酸（CA）组成的γ射线诱导聚电解质共聚水凝胶在尿素溶液中的平衡溶胀特性。含不同量CA的聚（丙烯酰胺-共-巴豆酸）[poly(AAm-co-CA)]水凝胶在辐射后呈棒状。在25℃下于尿素水溶液中进行重量法溶胀实验。水凝胶在（尿素/水）水性介质中表现出很大程度的溶胀，溶胀高度依赖于水凝胶的化学组成和辐照剂量。聚（AAm-co-CA）水凝胶的溶胀百分比在1160%至4250%之间，而AAm水凝胶的溶胀百分比在670%至900%之间。扩散指数值（n）在0.51至0.66之间，因此尿素/水向水凝胶中的扩散是非菲克扩散。水凝胶体系的平衡尿素/水含量在0.870至0.977之间变化。
