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Cyclic urea derivatives as potent NK1 selective antagonists.

作者信息

Shue Ho-Jane, Chen Xiao, Shih Neng-Yang, Blythin David J, Paliwal Sunil, Lin Ling, Gu Danlin, Schwerdt John H, Shah Sapna, Reichard Gregory A, Piwinski John J, Duffy Ruth A, Lachowicz Jean E, Coffin Vicki L, Liu Fei, Nomeir Amin A, Morgan Cynthia A, Varty Geoffrey B

机构信息

Chemical Research Department, Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA.

出版信息

Bioorg Med Chem Lett. 2005 Sep 1;15(17):3896-9. doi: 10.1016/j.bmcl.2005.05.111.

DOI:10.1016/j.bmcl.2005.05.111
PMID:16019209
Abstract

A series of novel five- and six-membered ring urea derivatives have been described as potent and selective NK1 receptor antagonists. Several compounds in this series exhibited good oral activity and brain penetration. Syntheses of these compounds are also described herein.

摘要

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