Wager Tor D, Sylvester Ching-Yune C, Lacey Steven C, Nee Derek Evan, Franklin Michael, Jonides John
Department of Psychology, Columbia University, 1190 Amsterdam Avenue, New York, NY 10027, USA.
Neuroimage. 2005 Aug 15;27(2):323-40. doi: 10.1016/j.neuroimage.2005.01.054.
The ability to inhibit inappropriate responses is central to cognitive control, but whether the same brain mechanisms mediate inhibition across different tasks is not known. We present evidence for a common set of frontal and parietal regions engaged in response inhibition across three tasks: a go/no-go task, a flanker task, and a stimulus-response compatibility task. Regions included bilateral anterior insula/frontal operculum and anterior prefrontal, right dorsolateral and premotor, and parietal cortices. Insula activity was positively correlated with interference costs in behavioral performance in each task. Principal components analysis showed a coherent pattern of individual differences in these regions that was also positively correlated with performance in all three tasks. However, correlations among tasks were low, for both brain activity and performance. We suggest that common interference detection and/or resolution mechanisms are engaged across tasks, and that inter-task correlations in behavioral performance are low because they conflate measurements of common mechanisms with measurements of individual biases unique to each task.
抑制不适当反应的能力是认知控制的核心，但相同的脑机制是否在不同任务中介导抑制作用尚不清楚。我们提供证据表明，在三个任务中存在一组共同的额叶和顶叶区域参与反应抑制：一个“去/不去”任务、一个侧翼任务和一个刺激-反应相容性任务。这些区域包括双侧前岛叶/额下回和前额叶前部、右侧背外侧和运动前区以及顶叶皮质。岛叶活动与每个任务中行为表现的干扰成本呈正相关。主成分分析显示这些区域存在一致的个体差异模式，且与所有三个任务的表现也呈正相关。然而，无论是脑活动还是表现，任务之间的相关性都很低。我们认为，跨任务会启用共同的干扰检测和/或解决机制，行为表现的任务间相关性较低是因为它们将共同机制的测量与每个任务特有的个体偏差测量混在一起。
