Nakata Hiroki, Sakamoto Kiwako, Ferretti Antonio, Gianni Perrucci Mauro, Del Gratta Cosimo, Kakigi Ryusuke, Luca Romani Gian
ITAB-Institute for Advanced Biomedical Technologies, Gabriele D'Annunzio University Foundation, Chieti, Italy.
Neuroimage. 2008 Feb 15;39(4):1858-66. doi: 10.1016/j.neuroimage.2007.10.041. Epub 2007 Nov 7.
Inhibiting inappropriate behavior and thoughts is an essential ability for humans, but the regions responsible for inhibitory processing are a matter of continuous debate. This is the first study of somatosensory go/nogo tasks using event-related functional magnetic resonance imaging (fMRI). Fifteen subjects preformed two different types of go/nogo task, i.e. (1) Movement and (2) Count, to compare with previous studies using visual go/nogo tasks, and confirm whether the inhibitory processing is dependent on sensory modalities. Go and nogo stimuli were presented with an even probability. Our data indicated that the response inhibition network involved the dorsolateral (DLPFC) and ventrolateral (VLPFC) prefrontal cortices, pre-supplementary motor area (pre-SMA), anterior cingulate cortex (ACC), inferior parietal lobule (IPL), insula, and temporoparietal junction (TPJ), which were consistent with previous results obtained using visual go/nogo tasks. These activities existed in both Movement and Count Nogo trials. Therefore, our results suggest that the network for inhibitory processing is not dependent on sensory modalities but reflects common neural activities. In addition, there were differences of activation intensity between Movement and Count Nogo trials in the prefrontal cortex, temporal lobe, and ACC. Thus, inhibitory processing would involve two neural networks, common and uncommon regions, depending on the required response mode.
抑制不适当的行为和想法是人类的一项基本能力，但负责抑制性加工的脑区一直存在争议。这是第一项使用事件相关功能磁共振成像（fMRI）对体感去/不去任务进行的研究。15名受试者执行了两种不同类型的去/不去任务，即（1）运动和（2）计数，以与之前使用视觉去/不去任务的研究进行比较，并确认抑制性加工是否依赖于感觉模态。去和不去刺激以相等的概率呈现。我们的数据表明，反应抑制网络涉及背外侧前额叶皮质（DLPFC）、腹外侧前额叶皮质（VLPFC）、前辅助运动区（pre-SMA）、前扣带回皮质（ACC）、顶下小叶（IPL）、脑岛和颞顶联合区（TPJ），这与之前使用视觉去/不去任务获得的结果一致。这些活动在运动和计数不去试验中均存在。因此，我们的结果表明，抑制性加工网络不依赖于感觉模态，而是反映了共同的神经活动。此外，运动和计数不去试验在额叶皮质、颞叶和ACC的激活强度存在差异。因此，抑制性加工将涉及两个神经网络，即共同区域和非共同区域，这取决于所需的反应模式。
