Augoulea Areti, Mastorakos George, Lambrinoudaki Irene, Christodoulakos George, Creatsas George
Second Department of Obstetrics and Gynecology, Aretaieion Hospital, University of Athens, Greece.
Gynecol Endocrinol. 2005 Apr;20(4):227-35. doi: 10.1080/09513590400027372.
During menopause women tend to gain body fat. The increase in adiposity seems to be a consequence of the decline in endogenous estrogens and the reduced energy expenditure. The role of post-menopausal hormone replacement therapy (pHT) in modulating visceral obesity is controversial. Some studies have shown that pHT has no effect on body weight while in other studies pHT increased body weight. Leptin is an adipocyte-derived hormone and its levels reflect the amount of adipose tissue. Obesity is associated with elevated serum leptin levels. The effect of pHT on leptin levels is also controversial. In some studies pHT increased leptin levels while other studies have not confirmed this increasing effect. The major problem encountered during administration of hormone therapy seems to be the timing of pHT initiation which is a strong confounder on the effect of pHT on leptin levels in postmenopausal women.
在更年期期间，女性往往会增加体脂。肥胖的增加似乎是内源性雌激素下降和能量消耗减少的结果。绝经后激素替代疗法（pHT）在调节内脏肥胖方面的作用存在争议。一些研究表明，pHT对体重没有影响，而在其他研究中，pHT会增加体重。瘦素是一种由脂肪细胞产生的激素，其水平反映了脂肪组织的数量。肥胖与血清瘦素水平升高有关。pHT对瘦素水平的影响也存在争议。在一些研究中，pHT会增加瘦素水平，而其他研究并未证实这种增加效应。激素治疗过程中遇到的主要问题似乎是pHT开始的时间，这是pHT对绝经后女性瘦素水平影响的一个强大混杂因素。
